Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder

Liliana Laskaris; Sam Mancuso; Cynthia Shannon Weickert; Andrew Zalesky; Gursharan Chana; Cassandra Wannan; Chad Bousman; Bernhard T Baune; Patrick McGorry; Christos Pantelis; Vanessa L Cropley

Journal article

Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder

Liliana Laskaris, Sam Mancuso, Cynthia Shannon Weickert, Andrew Zalesky, Gursharan Chana, Cassandra Wannan, Chad Bousman, Bernhard T Baune, Patrick McGorry, Christos Pantelis, Vanessa L Cropley

Brain, Behavior, and Immunity | Elsevier | Published : 2021

DOI: 10.1016/j.bbi.2021.04.002

Abstract

Deficits in brain morphology are one of the most widely replicated neuropathological features in schizophrenia-spectrum disorder (SSD), although their biological underpinnings remain unclear. Despite the existence of hypotheses by which peripheral inflammation may impact brain structure, few studies have examined this relationship in SSD. This study aimed to establish the relationship between peripheral markers of inflammation and brain morphology and determine whether such relationships differed across healthy controls and individuals with first episode psychosis (FEP) and chronic schizophrenia. A panel of 13 pro- and anti-inflammatory cytokines were quantified from serum in 175 participant..

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University of Melbourne Researchers

Andrew Zalesky Author

Gursharan Chana Author

Cassandra Wannan Author

Bernhard Baune Author

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Grants

Awarded by National Alliance for Research on Schizophrenia and Depression

Funding Acknowledgements

This work was supported by an Australian National Health and Medical Research Council (NHMRC) Project Grant (1065742) and University of Melbourne Early Career Researcher grant (601253) to Vanessa Cropley; and a Royal Melbourne Hospital Grant in Aid (GIA-030-2016) and NARSAD Distinguished Investigator Grant to Christos Pantelis (18722).